2597056-04-5

2597056-04-5 structure

Name: PD-1/PD-L1-IN-23
Chemical Name: PD-1/PD-L1-IN-23
CAS Number: 2597056-04-5
Molecular Formula: C₃₂H₃₀BrCl₂N₃O₆
Molecular Weight: 703.41
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2022-04-06 20:26:21
Modify Date: 2024-01-11 22:21:45
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].

Name	PD-1/PD-L1-IN-23

Description	PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	PD-1/PD-L1[1]
References	[1]. Liu L, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021;64(12):8391-8409.

Molecular Formula	C₃₂H₃₀BrCl₂N₃O₆
Molecular Weight	703.41