Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (1R,2R)-ML-SI3
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Purity: 99.0%
Stocking Period: 10 Day
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2418594-00-8

2418594-00-8 structure

2418594-00-8 structure

Name: (1R,2R)-ML-SI3
Chemical Name: (1R,2R)-ML-SI3
CAS Number: 2418594-00-8
Molecular Formula: C₂₃H₃₁N₃O₃S
Molecular Weight: 429.58
Create Date: 2022-05-25 16:40:01
Modify Date: 2025-11-30 09:01:32
(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3[1].

Name	(1R,2R)-ML-SI3

Description	(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	TRPML1:1.6 μM (IC50) TRPML2:2.3 μM (IC50) TRPML3:12.5 μM (IC50)
References	[1]. Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966.

Molecular Formula	C₂₃H₃₁N₃O₃S
Molecular Weight	429.58

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