1030133-34-6

1030133-34-6 structure
1030133-34-6 structure
  • Name: Cas9-IN-2
  • Chemical Name: Cas9-IN-2
  • CAS Number: 1030133-34-6
  • Molecular Formula: C21H27N5O4S2
  • Molecular Weight: 477.60
  • Create Date: 2022-05-29 10:20:19
  • Modify Date: 2024-01-08 11:23:29
  • Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

Name Cas9-IN-2
Description Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].
Related Catalog
In Vitro Cas9-IN-1 (compound 2) (200 and 500 μM; overnight) helps the E. coli selection strain to survive SpyCas9-induced killing[1].
References

[1]. Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65(4):3266-3305.

Molecular Formula C21H27N5O4S2
Molecular Weight 477.60
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