2495750-19-9

2495750-19-9 structure

Name: LC kinetic stabilizer-1
Chemical Name: LC kinetic stabilizer-1
CAS Number: 2495750-19-9
Molecular Formula: C₂₇H₃₁N₅O₃
Molecular Weight: 473.57
Create Date: 2022-06-22 18:43:41
Modify Date: 2024-01-12 17:32:34
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL* and WIL-FL* T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer[1].

Name	LC kinetic stabilizer-1

Description	LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL* and WIL-FL* T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Yan NL, et al. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022;60:128571.

Molecular Formula	C₂₇H₃₁N₅O₃
Molecular Weight	473.57