2703134-40-9
2703134-40-9 structure
- Name: Bcl-2-IN-4
- Chemical Name: Bcl-2-IN-4
- CAS Number: 2703134-40-9
- Molecular Formula: C46H50ClN9O7S
- Molecular Weight: 908.46
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2022-08-17 10:00:28
- Modify Date: 2024-01-02 01:00:53
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Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1].
| Name | Bcl-2-IN-4 |
|---|
| Description | Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1]. |
|---|---|
| Related Catalog | |
| Target |
Bcl-2:1.5 nM (IC50) Bcl-xL:411 nM (IC50) |
| References |
[1]. Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1. |
| Molecular Formula | C46H50ClN9O7S |
|---|---|
| Molecular Weight | 908.46 |