2650640-17-6
2650640-17-6 structure
- Name: CDK9-IN-14
- Chemical Name: CDK9-IN-14
- CAS Number: 2650640-17-6
- Molecular Formula: C21H23F2N3O4
- Molecular Weight: 419.42
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-05-30 13:51:17
- Modify Date: 2024-01-14 12:53:43
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CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1].
| Name | CDK9-IN-14 |
|---|
| Description | CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK9:6.92 nM (IC50) |
| In Vitro | CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1]. |
| In Vivo | CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1]. Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1] Dosage: 5 mg/kg Administration: p.o., qd, for 9 days Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%. |
| References |
[1]. WANG Zhenyu. Compound as cyclin-dependent kinase 9 inhibitor and use thereof. WO2021115335A1 |
| Molecular Formula | C21H23F2N3O4 |
|---|---|
| Molecular Weight | 419.42 |