2580940-76-5

2580940-76-5 structure

Name: Dot1L-IN-7
Chemical Name: Dot1L-IN-7
CAS Number: 2580940-76-5
Molecular Formula: C₂₃H₂₇N₉O₂
Molecular Weight: 461.52
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2022-06-10 22:26:24
Modify Date: 2024-09-15 19:03:20
Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].

Name	Dot1L-IN-7

Description	Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	DOT1L:1 μM (IC50)
References	[1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.

Molecular Formula	C₂₃H₂₇N₉O₂
Molecular Weight	461.52