2764772-88-3
2764772-88-3 structure
- Name: EGFR-IN-46
- Chemical Name: EGFR-IN-46
- CAS Number: 2764772-88-3
- Molecular Formula: C27H32F3N3O3
- Molecular Weight: 503.56
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-05-21 07:27:01
- Modify Date: 2024-01-10 18:56:14
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EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1].
| Name | EGFR-IN-46 |
|---|
| Description | EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1]. |
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| Related Catalog | |
| Target |
EGFR:20.17 nM (IC50) FAK:14.25 nM (IC50) |
| In Vitro | EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively[1]. EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells[1]. EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1]. Cell Proliferation Assay[1] Cell Line: DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells Concentration: 10 µM Incubation Time: 24 h Result: Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively. Apoptosis Analysis[1] Cell Line: DLD1 cells Concentration: 3 µM Incubation Time: 24 h Result: Increased the total percentage of apoptotic cells from 7% to 90.33%. |
| References |
| Molecular Formula | C27H32F3N3O3 |
|---|---|
| Molecular Weight | 503.56 |