2759855-37-1
2759855-37-1 structure
- Name: HDAC1/MAO-B-IN-1
- Chemical Name: HDAC1/MAO-B-IN-1
- CAS Number: 2759855-37-1
- Molecular Formula: C18H17ClN2O2
- Molecular Weight: 328.79
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-05-30 10:37:05
- Modify Date: 2024-01-15 11:32:48
-
HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1].
| Name | HDAC1/MAO-B-IN-1 |
|---|
| Description | HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC1:21.4 nM (IC50) MAO-B:99.0 nM (IC50) |
| In Vitro | HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1]. HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1]. Cell Viability Assay[1] Cell Line: PC12 cells Concentration: 50 µM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production. |
| In Vivo | HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability[1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1]. Animal Model: 6-8 weeks, ICR male mice[1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice[1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice. |
| References |
| Molecular Formula | C18H17ClN2O2 |
|---|---|
| Molecular Weight | 328.79 |