2254502-89-9

2254502-89-9 structure

Name: HTT-D3
Chemical Name: HTT-D3
CAS Number: 2254502-89-9
Molecular Formula: C₂₃H₂₅FN₆
Molecular Weight: 404.48
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P-glycoprotein
Create Date: 2022-05-21 19:08:40
Modify Date: 2024-04-13 20:19:59
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1].

Name	HTT-D3

Description	HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Research Areas >> Neurological Disease
References	[1]. Anuradha Bhattacharyya, et al. Small molecule splicing modifiers with systemic HTT-lowering activity. Nat Commun. 2021 Dec 15;12(1):7299.

Molecular Formula	C₂₃H₂₅FN₆
Molecular Weight	404.48