2469044-23-1

2469044-23-1 structure

2469044-23-1 structure

Name: IDH2R140Q-IN-1
Chemical Name: IDH2R140Q-IN-1
CAS Number: 2469044-23-1
Molecular Formula: C₂₂H₂₀F₆N₆
Molecular Weight: 482.42
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2022-05-25 20:03:06
Modify Date: 2024-01-09 21:58:29
IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].

Name	IDH2R140Q-IN-1

Description	IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
References	[1]. Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491.

Molecular Formula	C₂₂H₂₀F₆N₆
Molecular Weight	482.42