2669785-84-4

2669785-84-4 structure

Name: JPS035
Chemical Name: JPS035
CAS Number: 2669785-84-4
Molecular Formula: C₄₉H₆₅N₇O₇S
Molecular Weight: 896.15
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-07-02 12:04:32
Modify Date: 2025-08-25 11:09:16
JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Name	JPS035

Description	JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659.

Molecular Formula	C₄₉H₆₅N₇O₇S
Molecular Weight	896.15