1197522-21-6

1197522-21-6 structure

Name: KIF18A-IN-4
Chemical Name: KIF18A-IN-4
CAS Number: 1197522-21-6
Molecular Formula: C₂₂H₂₇N₃O₃S
Molecular Weight: 413.53
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2022-06-30 17:27:21
Modify Date: 2024-01-09 16:37:45
KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].

Name	KIF18A-IN-4

Description	KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 6.16 μM (KIF18A)[1]
In Vitro	KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1]. KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1].
References	[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.

Molecular Formula	C₂₂H₂₇N₃O₃S
Molecular Weight	413.53