2304859-34-3
2304859-34-3 structure
- Name: Lipid-lowering agent-1
- Chemical Name: Lipid-lowering agent-1
- CAS Number: 2304859-34-3
- Molecular Formula: C26H19ClF3NO6S
- Molecular Weight: 565.95
- Catalog: Research Areas Others
- Create Date: 2022-06-02 20:46:20
- Modify Date: 2024-01-13 18:54:24
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Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats[1].
| Name | Lipid-lowering agent-1 |
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| Description | Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats[1]. |
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| Related Catalog | |
| In Vitro | Lipid-lowering agent-1 (compound 1m) (12.5 μM; 72 hours) does not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration[1]. Lipid-lowering agent-1 (10 μM; 24 hours) has significant pharmacological effects on the inhibition of LDLC and promotion of HDLC production[1]. Lipid-lowering agent-1 (10 μM; 24 hours) inhibits the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4%[1]. Lipid-lowering agent-1 (10 μM; 10 days) decreases yellow lipid droplets effectively in 3T3-L1 cells[1]. Cell Cytotoxicity Assay Cell Line: HepG2 and 3T3-L1[1] Concentration: 12.5 μM Incubation Time: 72 hours Result: Did not exhibit significant toxicity to both HepG2 and 3T3-L1 cells at a high concentration. Cell Differentiation Assay Cell Line: 3T3-L1 cells[1] Concentration: 10 μM Incubation Time: 24 hours Result: Inhibited the conversion of 3T3-L1 cells from pre-adipose to adipose-like with the inhibition of triglycerides (TG) by 70.4% |
| In Vivo | Lipid-lowering agent-1 (15 mg/kg; i.g., daily for 40 or 80 days) reduces blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes is still better than that of berberine after dosing 80 days[1]. Animal Model: High-fat diet (HFD) rats[1] Dosage: 15 mg/kg Administration: i.g., daily for 40 or 80 days Result: Reduced blood cholesterolby, triglycerides and LDLC by 19.6%, 34.52%, and 41.49% after dosing 40 days, moreover the three indexes was still better than that of berberine after dosing 80 days. |
| References |
| Molecular Formula | C26H19ClF3NO6S |
|---|---|
| Molecular Weight | 565.95 |