1257235-99-6

1257235-99-6 structure

Name: NU5455
Chemical Name: NU5455
CAS Number: 1257235-99-6
Molecular Formula: C₃₄H₃₃N₃O₅S
Molecular Weight: 595.71
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA-PK
Create Date: 2022-05-21 17:52:49
Modify Date: 2025-08-25 11:47:01
NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].

Name	NU5455

Description	NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
References	[1]. Willoughby CE, et al. Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. J Clin Invest. 2020;130(1):258-271.

Molecular Formula	C₃₄H₃₃N₃O₅S
Molecular Weight	595.71