NU5455

Modify Date: 2024-01-09 11:24:50

NU5455 Structure
NU5455 structure
Common Name NU5455
CAS Number 1257235-99-6 Molecular Weight 595.71
Density N/A Boiling Point N/A
Molecular Formula C34H33N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NU5455


NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].

 Names

Name NU5455

 NU5455 Biological Activity

Description NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].
Related Catalog
References

[1]. Willoughby CE, et al. Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. J Clin Invest. 2020;130(1):258-271.

 Chemical & Physical Properties

Molecular Formula C34H33N3O5S
Molecular Weight 595.71