2251017-69-1
2251017-69-1 structure
- Name: Orexin receptor antagonist 4
- Chemical Name: Orexin receptor antagonist 4
- CAS Number: 2251017-69-1
- Molecular Formula: C23H25FN4O2
- Molecular Weight: 408.47
- Catalog: Signaling Pathways GPCR/G Protein Orexin Receptor (OX Receptor)
- Create Date: 2022-05-20 20:34:25
- Modify Date: 2026-07-15 17:33:12
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Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].
| Name | Orexin receptor antagonist 4 |
|---|---|
| Synonyms |
Orexin rector antagonist 4
5-Pyrimidinecbonitrile, 2-[(3aS,4S,6-5-(2-fluoro-4-methoxybenzoyl)hexahydro-4-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl]-4,6-dimethyl |
| Description | Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1]. |
|---|---|
| Related Catalog | |
| Target |
OX2 Receptor:4.27 nM (IC50) OX1 Receptor:295 nM (IC50) |
| References |
[1]. David Sheppard, et al. Orexin receptor antagonists. WO2018206959A1 |
| Molecular Formula | C23H25FN4O2 |
|---|---|
| Molecular Weight | 408.47 |