Orexin receptor antagonist 4

Modify Date: 2025-09-18 12:38:26

Orexin receptor antagonist 4 structure	Common Name	Orexin receptor antagonist 4
	CAS Number	2251017-69-1	Molecular Weight	408.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₅FN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Orexin receptor antagonist 4

Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].

Name	Orexin receptor antagonist 4

Description	Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor) Research Areas >> Neurological Disease
Target	OX2 Receptor:4.27 nM (IC50) OX1 Receptor:295 nM (IC50)
References	[1]. David Sheppard, et al. Orexin receptor antagonists. WO2018206959A1

Molecular Formula	C₂₃H₂₅FN₄O₂
Molecular Weight	408.47
InChIKey	RPKQAICAULRXBF-KHYOSLBOSA-N
SMILES	COc1ccc(C(=O)N2CC3CN(c4nc(C)c(C#N)c(C)n4)CC3C2C)c(F)c1

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Orexin receptor antagonist 4

Use of Orexin receptor antagonist 4

Names

Orexin receptor antagonist 4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.