1359956-12-9

1359956-12-9 structure
1359956-12-9 structure
  • Name: PI3K-IN-31
  • Chemical Name: PI3K-IN-31
  • CAS Number: 1359956-12-9
  • Molecular Formula: C19H23F2N7O3
  • Molecular Weight: 435.43
  • Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
  • Create Date: 2022-05-28 12:20:42
  • Modify Date: 2024-01-11 10:45:04
  • PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].

Name PI3K-IN-31
Description PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].
Related Catalog
Target

PI3Kα:3.7 nM (IC50)

PI3Kδ:9.9 nM (IC50)

PI3Kγ:14.6 nM (IC50)

PI3Kβ:74 nM (IC50)

References

[1]. Marcian E Van Dort, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

Molecular Formula C19H23F2N7O3
Molecular Weight 435.43