PI3K-IN-31

Modify Date: 2024-01-11 10:45:04

PI3K-IN-31 structure	Common Name	PI3K-IN-31
	CAS Number	1359956-12-9	Molecular Weight	435.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃F₂N₇O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3K-IN-31

PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].

Name	PI3K-IN-31

Description	PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα:3.7 nM (IC50) PI3Kδ:9.9 nM (IC50) PI3Kγ:14.6 nM (IC50) PI3Kβ:74 nM (IC50)
References	[1]. Marcian E Van Dort, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

Molecular Formula	C₁₉H₂₃F₂N₇O₃
Molecular Weight	435.43