PI3K-IN-31

Modify Date: 2024-01-11 10:45:04

PI3K-IN-31 Structure
PI3K-IN-31 structure
Common Name PI3K-IN-31
CAS Number 1359956-12-9 Molecular Weight 435.43
Density N/A Boiling Point N/A
Molecular Formula C19H23F2N7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PI3K-IN-31


PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].

 Names

Name PI3K-IN-31

 PI3K-IN-31 Biological Activity

Description PI3K-IN-31 (Compound 6b) is a potent PI3K inhibitor with IC50s of 3.7 nM, 74 nM, 14.6 nM, and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. PI3K-IN-31 has anticancer effects[1].
Related Catalog
Target

PI3Kα:3.7 nM (IC50)

PI3Kδ:9.9 nM (IC50)

PI3Kγ:14.6 nM (IC50)

PI3Kβ:74 nM (IC50)

References

[1]. Marcian E Van Dort, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

 Chemical & Physical Properties

Molecular Formula C19H23F2N7O3
Molecular Weight 435.43