827001-82-1
827001-82-1 structure
- Name: 5J-4
- Chemical Name: 5J-4
- CAS Number: 827001-82-1
- Molecular Formula: C16H12N2O3S
- Molecular Weight: 312.34
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CRAC Channel
- Create Date: 2022-06-23 16:49:29
- Modify Date: 2025-08-25 11:39:23
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5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].
| Name | 5J-4 |
|---|
| Description | 5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1]. |
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| Related Catalog | |
| In Vivo | 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1]. 5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1]. Animal Model: C57BL/6 mice (MOG35-55 peptide-immunized mice)[1] Dosage: 2 m/kg Administration: I.p., every alternate day for 30 days Result: Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population. |
| References |
| Molecular Formula | C16H12N2O3S |
|---|---|
| Molecular Weight | 312.34 |