2410384-59-5

2410384-59-5 structure

Name: COX-2/5-LOX-IN-2
Chemical Name: COX-2/5-LOX-IN-2
CAS Number: 2410384-59-5
Molecular Formula: C₁₈H₁₃N₃O₄S₂
Molecular Weight: 399.44
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-07-06 16:58:23
Modify Date: 2024-04-09 16:02:07
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively[1].

Name	COX-2/5-LOX-IN-2

Description	COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 5.40, 0.01 and 1.78 μM, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
References	[1]. Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.

Molecular Formula	C₁₈H₁₃N₃O₄S₂
Molecular Weight	399.44