2548963-55-7

2548963-55-7 structure

Name: hA2A/hCA XII modulator 1
Chemical Name: hA2A/hCA XII modulator 1
CAS Number: 2548963-55-7
Molecular Formula: C₂₄H₁₉N₇O₄S
Molecular Weight: 501.52
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2022-07-04 16:16:44
Modify Date: 2024-01-24 17:39:20
hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].

Name	hA2A/hCA XII modulator 1

Description	hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	hA2AAR:6.4 nM (Ki) hA1AR:4.819 μM (Ki) hA3:>30 μM (Ki)
References	[1]. Costanza Ceni, et al. Discovery of first-in-class multi-target adenosine A 2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents. Eur J Med Chem. 2020 Sep 1;201:112478.

Molecular Formula	C₂₄H₁₉N₇O₄S
Molecular Weight	501.52