1862177-86-3
1862177-86-3 structure
- Name: COB-187
- Chemical Name: COB-187
- CAS Number: 1862177-86-3
- Molecular Formula: C15H14N2Os2
- Molecular Weight: 302.41
- Create Date: 2022-07-02 17:01:42
- Modify Date: 2024-05-02 09:53:27
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COB-187 (COB187) is a highly potent and selective inhibitor of GSK-3 with IC50 of 22/11 nM against GSK-3α/GSK-3β.COB-187 inhibits GSK-3 phosphorylation of β-catenin and, albeit to a lesser extent, glycogen synthase.COB-187 increases the protein level of β-catenin in RAW 264.7 macrophages.COB-187 enhances β-catenin localization to the perinuclear and nuclear region in THP-1 macrophage, does not change the β-catenin mRNA level.COB-187 significantly increases the expression of the Wnt target gene cyclin D1, reduces the phosphorylation of tau in HEK293 cells transfected with tau expression vector.COB-187 inhibits only 3 kinases at >40% in a panel of 414 kinase assays, more selective relative to Tideglusib.
| Name | COB-187 |
|---|
| Description | COB-187 (COB187) is a highly potent and selective inhibitor of GSK-3 with IC50 of 22/11 nM against GSK-3α/GSK-3β.COB-187 inhibits GSK-3 phosphorylation of β-catenin and, albeit to a lesser extent, glycogen synthase.COB-187 increases the protein level of β-catenin in RAW 264.7 macrophages.COB-187 enhances β-catenin localization to the perinuclear and nuclear region in THP-1 macrophage, does not change the β-catenin mRNA level.COB-187 significantly increases the expression of the Wnt target gene cyclin D1, reduces the phosphorylation of tau in HEK293 cells transfected with tau expression vector.COB-187 inhibits only 3 kinases at >40% in a panel of 414 kinase assays, more selective relative to Tideglusib. |
|---|---|
| References | 1. Noori MS, et al. Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1289-C1303. |
| Molecular Formula | C15H14N2Os2 |
|---|---|
| Molecular Weight | 302.41 |