2130881-32-0
2130881-32-0 structure
- Name: RTICBM-74
- Chemical Name: RTICBM-74
- CAS Number: 2130881-32-0
- Molecular Formula: C19H14ClFN2O
- Molecular Weight: 340.782
- Create Date: 2022-07-01 17:56:31
- Modify Date: 2024-04-06 20:26:08
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RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.
| Name | RTICBM-74 |
|---|
| Description | RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration. |
|---|---|
| References | 1. Nguyen T, et al. J Med Chem. 2017 Sep 14;60(17):7410-7424. 2. Lovelock DF, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):153-161. |
| Molecular Formula | C19H14ClFN2O |
|---|---|
| Molecular Weight | 340.782 |