2163769-52-4
2163769-52-4 structure
- Name: BAY-155
- Chemical Name: BAY-155
- CAS Number: 2163769-52-4
- Molecular Formula: C28H28F3N7Os
- Molecular Weight: 567.635
- Create Date: 2022-07-01 16:38:48
- Modify Date: 2024-04-08 20:21:25
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BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503;BAY-155 demonstrated a significantly enhanced selectivity profile compared to MI-503 in a panel of assays covering numerous safety pharmacology-relevant targets including GPCRs, ion channels and transporters.BAY-155 shows anti-proliferative activity in a large cell line panel, exhibits specific therapeutic activityin AML/ALL models.
| Name | BAY-155 |
|---|
| Description | BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503;BAY-155 demonstrated a significantly enhanced selectivity profile compared to MI-503 in a panel of assays covering numerous safety pharmacology-relevant targets including GPCRs, ion channels and transporters.BAY-155 shows anti-proliferative activity in a large cell line panel, exhibits specific therapeutic activityin AML/ALL models. |
|---|---|
| References | 1. Krzysztof Brzezinka, et al. Cancers (Basel). 2020 Jan 14;12(1):201. |
| Molecular Formula | C28H28F3N7Os |
|---|---|
| Molecular Weight | 567.635 |