2421117-94-2
2421117-94-2 structure
- Name: BC-DXI-495
- Chemical Name: BC-DXI-495
- CAS Number: 2421117-94-2
- Molecular Formula: C28H30N4O4S
- Molecular Weight: 518.632
- Create Date: 2022-07-02 18:11:45
- Modify Date: 2024-04-03 10:17:41
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BC-DXI-495 is a specific small molecule inhibitor of AIMP2-DX2-HSP70 interaction, specifically reduced the levels of DX2 (IC50=4.2 uM) but not AIMP2-F, and the viability of lung cancer cells (EC50=14 uM).BC-DXI-495 bound to DX2 with KD of 14 uM.BC-DXI-495 specifically reduced the levels of endogenous DX2 protein but not of AIMP2-F , affected the DX2 protein level, but not mRNA level.BC-DXI-495 inhibited DX2-dependent cell growth, significantly diminished tumor growth in a xenograft model of H460 cells, with little effect on body weigh.BC-DXI-495 significantly suppressed the growth and weight of tumors expressing DX2 WT, but not L80A mutant.
| Name | BC-DXI-495 |
|---|
| Description | BC-DXI-495 is a specific small molecule inhibitor of AIMP2-DX2-HSP70 interaction, specifically reduced the levels of DX2 (IC50=4.2 uM) but not AIMP2-F, and the viability of lung cancer cells (EC50=14 uM).BC-DXI-495 bound to DX2 with KD of 14 uM.BC-DXI-495 specifically reduced the levels of endogenous DX2 protein but not of AIMP2-F , affected the DX2 protein level, but not mRNA level.BC-DXI-495 inhibited DX2-dependent cell growth, significantly diminished tumor growth in a xenograft model of H460 cells, with little effect on body weigh.BC-DXI-495 significantly suppressed the growth and weight of tumors expressing DX2 WT, but not L80A mutant. |
|---|---|
| References | 1. Lim S, et al. Nat Chem Biol. 2020 Jan;16(1):31-41. |
| Molecular Formula | C28H30N4O4S |
|---|---|
| Molecular Weight | 518.632 |