2762552-74-7
2762552-74-7 structure
- Name: STING PROTAC SP23
- Chemical Name: STING PROTAC SP23
- CAS Number: 2762552-74-7
- Molecular Formula: C34H33N7O10
- Molecular Weight: 699.677
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2022-07-11 16:14:23
- Modify Date: 2024-04-06 18:05:36
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SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.
| Name | STING PROTAC SP23 |
|---|
| Description | SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway. |
|---|---|
| References | 1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948. |
| Molecular Formula | C34H33N7O10 |
|---|---|
| Molecular Weight | 699.677 |