878453-71-5
878453-71-5 structure
- Name: V-0219
- Chemical Name: V-0219
- CAS Number: 878453-71-5
- Molecular Formula: C20H25F3N4O2
- Molecular Weight: 410.441
- Catalog: Signaling Pathways GPCR/G Protein Glucagon Receptor
- Create Date: 2022-08-31 21:28:46
- Modify Date: 2025-09-06 12:21:47
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V-0219 is a small molecule positive allosteric modulator (PAM) of GLP-1R with Emax of 60% in the cAMP assay.V-0219 potentiated insulin secretion in INS-1 β-cells with EC50 of 0.25 nM, the best response was observed at 0.1 nM, when a fixed concentration of 0.2 nM of GLP-1 was added to the dose-response curve of 9, the maximal response observed reached a plateau at 0.1 nM, with an EC50 value of 0.008 nM.V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents.
| Name | V-0219 |
|---|
| Description | V-0219 is a small molecule positive allosteric modulator (PAM) of GLP-1R with Emax of 60% in the cAMP assay.V-0219 potentiated insulin secretion in INS-1 β-cells with EC50 of 0.25 nM, the best response was observed at 0.1 nM, when a fixed concentration of 0.2 nM of GLP-1 was added to the dose-response curve of 9, the maximal response observed reached a plateau at 0.1 nM, with an EC50 value of 0.008 nM.V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents. |
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| References | 1. Juan M. Decara, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.1c01842 |
| Molecular Formula | C20H25F3N4O2 |
|---|---|
| Molecular Weight | 410.441 |