V-0219
Modify Date: 2024-07-17 10:01:03
V-0219 structure
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Common Name | V-0219 | ||
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| CAS Number | 878453-71-5 | Molecular Weight | 410.441 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H25F3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of V-0219V-0219 is a small molecule positive allosteric modulator (PAM) of GLP-1R with Emax of 60% in the cAMP assay.V-0219 potentiated insulin secretion in INS-1 β-cells with EC50 of 0.25 nM, the best response was observed at 0.1 nM, when a fixed concentration of 0.2 nM of GLP-1 was added to the dose-response curve of 9, the maximal response observed reached a plateau at 0.1 nM, with an EC50 value of 0.008 nM.V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents. |
| Name | V-0219 |
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| Description | V-0219 is a small molecule positive allosteric modulator (PAM) of GLP-1R with Emax of 60% in the cAMP assay.V-0219 potentiated insulin secretion in INS-1 β-cells with EC50 of 0.25 nM, the best response was observed at 0.1 nM, when a fixed concentration of 0.2 nM of GLP-1 was added to the dose-response curve of 9, the maximal response observed reached a plateau at 0.1 nM, with an EC50 value of 0.008 nM.V-0219 shows a remarkable in vivo activity, reducing food intake and improving glucose handling in normal and diabetic rodents. |
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| References | 1. Juan M. Decara, et al. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.1c01842 |
| Molecular Formula | C20H25F3N4O2 |
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| Molecular Weight | 410.441 |