2247950-73-6
2247950-73-6 structure
- Name: KYN-101
- Chemical Name: KYN-101
- CAS Number: 2247950-73-6
- Molecular Formula: C22H19FN6
- Molecular Weight: 386.434
- Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
- Create Date: 2022-07-01 10:55:10
- Modify Date: 2024-01-10 16:36:17
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KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO.
| Name | KYN-101 |
|---|
| Description | KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO. |
|---|---|
| References | 1. Luis Felipe Campesato, et al. Nat Commun. 2020 Aug 11;11(1):4011. |
| Molecular Formula | C22H19FN6 |
|---|---|
| Molecular Weight | 386.434 |