KYN-101
Modify Date: 2024-01-10 16:36:17
KYN-101 structure
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Common Name | KYN-101 | ||
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| CAS Number | 2247950-73-6 | Molecular Weight | 386.434 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H19FN6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KYN-101KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO. |
| Name | KYN-101 |
|---|
| Description | KYN-101 (KYN101) is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO. |
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| References | 1. Luis Felipe Campesato, et al. Nat Commun. 2020 Aug 11;11(1):4011. |
| Molecular Formula | C22H19FN6 |
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| Molecular Weight | 386.434 |