2341840-98-8
2341840-98-8 structure
- Name: dBRD9 dihydrochloride
- Chemical Name: dBRD9 dihydrochloride
- CAS Number: 2341840-98-8
- Molecular Formula: C40H47Cl2N7O10
- Molecular Weight: 856.755
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-08-05 15:13:19
- Modify Date: 2024-04-09 23:01:01
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dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.dBRD9 exhibits antiproliferative effects in human AML cell lines.
| Name | dBRD9 dihydrochloride |
|---|
| Description | dBRD9 dihydrochloride is a potent and selective degrader (PROTAC) of BRD9 with IC50 of 56.6 nM in MOLM-13 cells.dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide.dBRD9 does not degrade BRD4 or BRD7 at concentrations up to 5 uM.dBRD9 exhibits antiproliferative effects in human AML cell lines. |
|---|---|
| References | 1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. |
| Molecular Formula | C40H47Cl2N7O10 |
|---|---|
| Molecular Weight | 856.755 |