825658-63-7
825658-63-7 structure
- Name: RTI-7470-44
- Chemical Name: RTI-7470-44
- CAS Number: 825658-63-7
- Molecular Formula: C19H11ClF3N5Os
- Molecular Weight: 449.836
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-07-06 17:55:17
- Modify Date: 2024-01-02 14:00:36
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RTI-7470-44 is a potent, selective human trace amine-associated receptor subtype 1 (hTAAR1) antagonist with IC50 of 8.4 nM in vitro cAMP functional assay.RTI-7470-44 exhibits a Ki of 0.3 nM in a radioligand binding assay, and shows species selectivity (>90-fold) for hTAAR1 over the rat and mouse orthologues.RTI-7470-44 displays good blood–brain barrier permeability, moderate metabolic stability, and a favorable preliminary off-target profile.RTI-7470-44 increased the spontaneous firing rate of mouse VTA dopaminergic neurons and blocked the effects of the known TAAR1 agonist RO5166017.
| Name | RTI-7470-44 |
|---|
| Description | RTI-7470-44 is a potent, selective human trace amine-associated receptor subtype 1 (hTAAR1) antagonist with IC50 of 8.4 nM in vitro cAMP functional assay.RTI-7470-44 exhibits a Ki of 0.3 nM in a radioligand binding assay, and shows species selectivity (>90-fold) for hTAAR1 over the rat and mouse orthologues.RTI-7470-44 displays good blood–brain barrier permeability, moderate metabolic stability, and a favorable preliminary off-target profile.RTI-7470-44 increased the spontaneous firing rate of mouse VTA dopaminergic neurons and blocked the effects of the known TAAR1 agonist RO5166017. |
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| References | 1. Ann M Decker, et al. ACS Chem Neurosci. 2022 Mar 24. doi: 10.1021/acschemneuro.2c00086. |
| Molecular Formula | C19H11ClF3N5Os |
|---|---|
| Molecular Weight | 449.836 |