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  • DC Chemicals Limited
  • China
  • Product Name: HS-243
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

848249-10-5

848249-10-5 structure
848249-10-5 structure
  • Name: HS-243
  • Chemical Name: HS-243
  • CAS Number: 848249-10-5
  • Molecular Formula: C17H16N4O3
  • Molecular Weight: 324.34
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2022-07-19 10:52:06
  • Modify Date: 2024-09-19 16:00:51
  • HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.

Name HS-243
Description HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.
References 1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574.
Molecular Formula C17H16N4O3
Molecular Weight 324.34
Storage condition -20°C