2416910-82-0

2416910-82-0 structure

Name: AChE/BChE/MAO-B-IN-1
Chemical Name: AChE/BChE/MAO-B-IN-1
CAS Number: 2416910-82-0
Molecular Formula: C₂₀H₂₄N₂O₂
Molecular Weight: 324.42
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-07-02 10:54:05
Modify Date: 2024-01-12 19:03:49
AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].

Name	AChE/BChE/MAO-B-IN-1

Description	AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	MAO-B:26.1 μM (IC50) hAChE:7.31 μM (IC50) hBChE:0.56 μM (IC50)
In Vitro	AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β1-42 (Aβ1-42)-induced neuronal cell death[1].
References	[1]. Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

Molecular Formula	C₂₀H₂₄N₂O₂
Molecular Weight	324.42