AChE/BChE/MAO-B-IN-1

Modify Date: 2024-01-12 19:03:49

AChE/BChE/MAO-B-IN-1 Structure
AChE/BChE/MAO-B-IN-1 structure
Common Name AChE/BChE/MAO-B-IN-1
CAS Number 2416910-82-0 Molecular Weight 324.42
Density N/A Boiling Point N/A
Molecular Formula C20H24N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AChE/BChE/MAO-B-IN-1


AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].

 Names

Name AChE/BChE/MAO-B-IN-1

 AChE/BChE/MAO-B-IN-1 Biological Activity

Description AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependent AChE, BChE and MAO-B inhibitor with IC50 values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity[1].
Related Catalog
Target

MAO-B:26.1 μM (IC50)

hAChE:7.31 μM (IC50)

hBChE:0.56 μM (IC50)

In Vitro AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β1-42 (Aβ1-42)-induced neuronal cell death[1].
References

[1]. Košak U, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282.

 Chemical & Physical Properties

Molecular Formula C20H24N2O2
Molecular Weight 324.42