407587-01-3

407587-01-3 structure

Name: ANO1-IN-1
Chemical Name: ANO1-IN-1
CAS Number: 407587-01-3
Molecular Formula: C₁₈H₂₈N₂O₂S
Molecular Weight: 336.49
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2022-06-26 12:01:35
Modify Date: 2024-01-07 10:40:59
ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].

Name	ANO1-IN-1

Description	ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Target	IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]
In Vitro	ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells[1]. ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells[1].
References	[1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

Molecular Formula	C₁₈H₂₈N₂O₂S
Molecular Weight	336.49