637314-12-6

637314-12-6 structure

Name: ANO1-IN-2
Chemical Name: ANO1-IN-2
CAS Number: 637314-12-6
Molecular Formula: C₁₆H₁₄ClN₃O₂S₂
Molecular Weight: 379.88
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2022-06-25 22:37:21
Modify Date: 2024-01-02 14:48:54
ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC50 of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells[1].

Name	ANO1-IN-2

Description	ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC50 of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Target	IC50: 1.75 μM (ANO1), 7.43 μM (ANO2)[1]
In Vitro	ANO1-IN-2 (Compound 10q) (10 μM) significantly suppresses migration and invasion of U251 cells[1].
References	[1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

Molecular Formula	C₁₆H₁₄ClN₃O₂S₂
Molecular Weight	379.88