2529657-32-5

2529657-32-5 structure

Name: Anticancer agent 63
Chemical Name: Anticancer agent 63
CAS Number: 2529657-32-5
Molecular Formula: C₁₇H₂₄F₃NOSe
Molecular Weight: 394.33
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-06-30 12:19:36
Modify Date: 2024-01-06 19:33:30
Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].

Name	Anticancer agent 63

Description	Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase-3 Bcl-2
References	[1]. He X, et al. Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents. Eur J Med Chem. 2020 Dec 15;208:112864.

Molecular Formula	C₁₇H₂₄F₃NOSe
Molecular Weight	394.33