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2418014-98-7

2418014-98-7 structure

2418014-98-7 structure

Name: ART-IN-1
Chemical Name: ART-IN-1
CAS Number: 2418014-98-7
Molecular Formula: C₁₄H₁₃NO₂S
Molecular Weight: 259.32
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2022-07-01 20:50:40
Modify Date: 2024-04-06 10:56:55
ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].

Name	ART-IN-1

Description	ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	TNKS2:22 μM (IC50) PARP15:1.1 μM (IC50) PARP2:19 μM (IC50) PARP14:>100 μM (IC50) PARP10:2.4 μM (IC50)
In Vitro	ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].
References	[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.

Molecular Formula	C₁₄H₁₃NO₂S
Molecular Weight	259.32

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