2709031-17-2

2709031-17-2 structure

Name: AT2R antagonist 1
Chemical Name: AT2R antagonist 1
CAS Number: 2709031-17-2
Molecular Formula: C₂₃H₃₀N₄O₄S₂
Molecular Weight: 490.64
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2022-06-28 16:44:21
Modify Date: 2024-01-02 16:21:57
AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common drug-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1].

Name	AT2R antagonist 1

Description	AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common drug-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Target	Ki: 29 nM (AT2R), 1000 nM (AT1R)[1]
In Vitro	AT2R antagonist 1 (compound 21) exhibits a negligible inhibition of CYP 3A (5%) and a very low tendency to inhibit CYP 2D6 (12%), 2C8 (26%), 2C9 (23%) and 2B6 (24%)[1].
References	[1]. Bolteau R, et al. Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine. Eur J Med Chem. 2020 Mar 1;189:112078.

Molecular Formula	C₂₃H₃₀N₄O₄S₂
Molecular Weight	490.64