2459916-56-2

2459916-56-2 structure

Name: CDK1/Cyc B-IN-1
Chemical Name: CDK1/Cyc B-IN-1
CAS Number: 2459916-56-2
Molecular Formula: C₁₄H₁₂ClN₃O₂S₂
Molecular Weight: 353.85
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-01 18:16:20
Modify Date: 2024-01-28 16:46:12
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].

Name	CDK1/Cyc B-IN-1

Description	CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK1-Cyclin B:97 nM (IC50)
In Vitro	CDK1/Cyc B-IN-1 (Compound 5) shows cytotoxic activity with IC50 values of 5.33 ± 0.69 µM and 21.69 ± 1.04 µM against HCT-116 and WI-38, respectively[1].
References	[1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.

Molecular Formula	C₁₄H₁₂ClN₃O₂S₂
Molecular Weight	353.85