2428387-82-8

2428387-82-8 structure

2428387-82-8 structure

Name: COX-1/2-IN-3
Chemical Name: COX-1/2-IN-3
CAS Number: 2428387-82-8
Molecular Formula: C₁₄H₈N₂O₈
Molecular Weight: 332.22
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-16 17:52:03
Modify Date: 2024-07-18 16:10:20
COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity[1].

Name	COX-1/2-IN-3

Description	COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1 COX-2
In Vivo	COX-1/2-IN-3 (Compound 7a) (1.25 and 0.625 mg/ear) exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity[1].
References	[1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549.

Molecular Formula	C₁₄H₈N₂O₈
Molecular Weight	332.22