2428387-48-6

2428387-48-6 structure

Name: COX-2-IN-14
Chemical Name: COX-2-IN-14
CAS Number: 2428387-48-6
Molecular Formula: C₁₈H₁₈N₄O₆
Molecular Weight: 386.36
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-07-02 14:25:47
Modify Date: 2025-08-27 16:41:14
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].

Name	COX-2-IN-14

Description	COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
References	[1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549.

Molecular Formula	C₁₈H₁₈N₄O₆
Molecular Weight	386.36