2304749-86-6

2304749-86-6 structure

Name: CXCR4 antagonist 5
Chemical Name: CXCR4 antagonist 5
CAS Number: 2304749-86-6
Molecular Formula: C₂₁H₃₀N₆
Molecular Weight: 366.50
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2022-07-01 17:53:38
Modify Date: 2024-01-21 20:07:59
CXCR4 antagonist 5 (compound 23) is a highly potent CXCR4 antagonist with an IC50 value of 8.8 nM. CXCR4 antagonist 5 can inhibit CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis. CXCR4 antagonist 5 has good physicochemical properties and in vitro safety profiles, inhibiting CYP isozymes and hERG marginally or moderately[1].

Name	CXCR4 antagonist 5

Description	CXCR4 antagonist 5 (compound 23) is a highly potent CXCR4 antagonist with an IC50 value of 8.8 nM. CXCR4 antagonist 5 can inhibit CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis. CXCR4 antagonist 5 has good physicochemical properties and in vitro safety profiles, inhibiting CYP isozymes and hERG marginally or moderately[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:8.8 nM (IC50)
References	[1]. Zhu F, et al. Structural optimization of aminopyrimidine-based CXCR4 antagonists. Eur J Med Chem. 2020;187:111914.

Molecular Formula	C₂₁H₃₀N₆
Molecular Weight	366.50