2611459-57-3

2611459-57-3 structure

Name: EphA2 agonist 1
Chemical Name: EphA2 agonist 1
CAS Number: 2611459-57-3
Molecular Formula: C₅₀H₅₈N₁₂O₁₂
Molecular Weight: 1019.07
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Ephrin Receptor
Create Date: 2022-07-01 09:29:38
Modify Date: 2024-01-10 21:07:10
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation[1].

Name	EphA2 agonist 1

Description	EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor
Target	EphA2[1]
In Vitro	EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC50 values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].
References	[1]. Orahoske CM, et al. Dimeric small molecule agonists of EphA2 receptor inhibit glioblastoma cell growth. Bioorg Med Chem. 2020 Sep 15;28(18):115656.

Molecular Formula	C₅₀H₅₈N₁₂O₁₂
Molecular Weight	1019.07