2489446-47-9

2489446-47-9 structure

Name: FLT3/ITD-IN-3
Chemical Name: FLT3/ITD-IN-3
CAS Number: 2489446-47-9
Molecular Formula: C₂₂H₂₆ClN₇O₂
Molecular Weight: 455.94
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2022-07-01 09:33:56
Modify Date: 2024-04-05 17:42:18
FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 0.9 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

Name	FLT3/ITD-IN-3

Description	FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 0.9 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 0.9 nM (FLT3-ITD)[1]
References	[1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

Molecular Formula	C₂₂H₂₆ClN₇O₂
Molecular Weight	455.94