FLT3/ITD-IN-3

Modify Date: 2024-04-05 17:42:18

FLT3/ITD-IN-3 Structure
FLT3/ITD-IN-3 structure
 Common Name FLT3/ITD-IN-3
CAS Number 2489446-47-9 Molecular Weight 455.94
Density N/A Boiling Point N/A
Molecular Formula C22H26ClN7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FLT3/ITD-IN-3


FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 0.9 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

 Names

Name FLT3/ITD-IN-3

 FLT3/ITD-IN-3 Biological Activity

Description FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 0.9 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
Related Catalog
Target

IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 0.9 nM (FLT3-ITD)[1]

References

[1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

 Chemical & Physical Properties

Molecular Formula C22H26ClN7O2
Molecular Weight 455.94
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Chemsrc provides FLT3/ITD-IN-3(CAS#:2489446-47-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of FLT3/ITD-IN-3 are included as well.>> amp version: FLT3/ITD-IN-3

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