2451479-86-8

2451479-86-8 structure

Name: hCAIX-IN-6
Chemical Name: hCAIX-IN-6
CAS Number: 2451479-86-8
Molecular Formula: C₁₈H₁₂N₂O₄S
Molecular Weight: 352.36
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-06-26 12:32:20
Modify Date: 2024-01-09 22:26:41
Compounds 6B and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6K was effective on HCA XII. Compounds 6B, 14g and 6K can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.

Name	hCAIX-IN-6

Description	Compounds 6B and 14g showed significant inhibitory effect on tumor related subtype HCA IX with low nanomolar potency, while 6K was effective on HCA XII. Compounds 6B, 14g and 6K can be considered as the leading molecules for the development of future cancer therapeutic drugs based on new mechanisms of action.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
References	[1]. Swain B,et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.

Molecular Formula	C₁₈H₁₂N₂O₄S
Molecular Weight	352.36